Free Ebook Water-Insoluble Drug Formulation, Second EditionFrom CRC Press
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Water-Insoluble Drug Formulation, Second EditionFrom CRC Press
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Scientists have attributed more than 40 percent of the failures in new drug development to poor biopharmaceutical properties, particularly water insolubility. Issues surrounding water insolubility can postpone, or completely derail, important new drug development. Even much-needed reformulation of currently marketed products can be significantly affected by these challenges.
Water Insolubility is the Primary Culprit in over 40% of New Drug Development Failures
The most comprehensive resource on the topic, this second edition of Water Insoluble Drug Formulation brings together a distinguished team of experts to provide the scientific background and step-by-step guidance needed to deal with solubility issues in drug development. Twenty-three chapters systematically describe solubility properties and their impact on formulation, from theory to industrial practice. With detailed discussion on how these properties contribute to solubilization and dissolution, the text also features six brand new chapters on water-insoluble drugs, exploring regulatory aspects, pharmacokinetic behavior, early phase formulation strategies, lipid based systems for oral delivery, modified release of insoluble drugs, and scalable manufacturing aspects. The book includes more than 15 water-insoluble drug delivery systems or technologies, illustrated with case studies featuring oral and parenteral applications. Highlighting the most current information and data available, this seminal volume reflects the significant progress that has been made in nearly all aspects of this field.
- Sales Rank: #2687383 in Books
- Published on: 2008-01-18
- Original language: English
- Number of items: 1
- Dimensions: 10.25" h x 7.50" w x 1.50" l, 3.00 pounds
- Binding: Hardcover
- 688 pages
Most helpful customer reviews
0 of 0 people found the following review helpful.
Great 'review' type book
By sheila matz
The book contains lots of helpful tables and ideas for preclinical as well as clinical formulation devleopment. It even goes on to describe the manufacturing of specific delivery systems for these insoluble molecules. Not only is the theory presented, but practicle applications are also well described.
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